ABSTRACT
To evaluate antiulcer effects of aqueous, chloroform and ethanol extracts prepared from the henna leaves in rats employing the pylorus ligation and aspirin induced models. Gastric ulcers induced in Swiss albino rats (200g, N=6) by oral administration of aspirin suspension and pylorus ligation. The antiulcer activity was assessed by determining and comparing the ulcer index in the test drug groups with that of the vehicle control and standard ranitidine. In case of aspirin induced ulcers, the chloroform extract showed significant reduction of ulcers in a dose dependent manner. The parameters taken to assess antiulcer activity were volume of gastric juice, free acidity, total acidity and ulcer index. The results indicated that aqueous, ethanol and chloroform extract significantly (p<0.001) decreased the volume of gastric acid secretions, free acidity and total acidity and ulcer index.
ABSTRACT
The effect of aqueous extract of Ficus bengalensis (FBE) was assessed in different acute and chronic gastric ulcer models in rats. Gastric ulcers induced in swiss albino rats (200g, N=6) by oral administration of aspirin suspension and pylorus ligation. The anti ulcer activity was assessed by determining and comparing the ulcer index in the test drug groups with that of the vehicle control and standard ranitidine & sucralfate. FBE, 250–500 mg/kg administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (51.28, 63.24% protection, P < 0.01 to P < 0.001), aspirin (28.94, 64.91 protection, P < 0.001). The parameters taken to assess antiulcer activity were pH of gastric juice, total acidity and ulcer index. The results indicated that aqueous extract significantly (p<0.05) Ph, total acidity and ulcer index. On the basis of histopathology analysis, The results indicate that FBE possesses antiulcer activity in a dose dependent manner.
ABSTRACT
The aim of this study was to investigate the analgesic, antipyretic properties of the various (chloroform, ethanol and water) extracts from leaf of Ficus bengalensis (Moraceae) in rats. Dose of the different extracts 200mg/kg, i.p. were significantly reduced (p<0.05). The analgesic activity of leaf of Ficus bengalensis was studied using hot-plate method and tail-immersion method in rats. The antipyretic activity of leaf of Ficus bengalensis was studied in Brewer’s yeast-induced pyrexia in rats. Ethanolic extract of leaf of Ficus bengalensis showed more significant activity, while, chloroform extract and water extract does not showed significant (p<0.05) analgesic activity as compared to standard drug using hot-plate method and by tail-immersion method. Extracts obtained were also subjected to evaluate antipyretic activity by yeast induced fevered rats. Aspirin (100mg/kg) was taken as standard drug. Water and chloroform extract showed significant decrease in elevated body temperature, while ethanol extract did not showed a significant (p<0.05) decrease in elevated body temperature as compared to standard drug.